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LONDON: British researchers have developed a method for ‘jumping time’ human cells with 30 years, turn back hours of aging for cells without losing their special functions. The team from the Babraham Institute at the University of Cambridge has been able to recover the function of older cells, and rejuvenate the molecular size of biological age. Although his findings, published in the Elife journal, are in the early stages of exploration, it can revolutionize regenerative drugs.
This new method solves the problem completely removing cell identity by stopping reprogramming parts of the process through the process. This allows researchers to find the right balance between reprogramming cells, making it younger biologically, while they can still recover their special cell function.
In 2007, Shiana Yamanaka was the first scientist to convert normal cells, which had certain functions, into stem cells that had special abilities to develop into any type of cell. The full process of re-programming of stem cells requires around 50 days using four main molecules called Yamanaka factors.The new method, called the ‘Tranary Phase Programming Program’, explained the cell to the Yamanaka factor for only 13 days. At this point, changes related to age are removed and cells lose temporary identity. Programmable cells are partially given time to grow under normal conditions, to observe whether their specific skin cell function is returned.
Genome analysis shows that cells have regained the characteristics of skin cells (fibroblasts), and this is confirmed by observing collagen production in reprogrammed cells.
“Our results represent a big step forward in our understanding of cell programming. We have proven that cells can be rejuvenated without losing their functions and that rejuvenation is seen restoring several functions to old cells,” said Dr. Diljeet Gill, a postdoc at The Institute. .
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